hrp0095p1-587 | Thyroid | ESPE2022

Sensitivity to Thyroid Hormones and Metabolic Syndrome in Pediatric Patients with Neuromotor Disability

Calcaterra Valeria , Biganzoli Giacomo , Ferraro Simona , Mari Alessandra , Rossi Virginia , Biganzoli Elia , Zuccotti Gianvincenzo

Introduction: Thyroid hormones (THs) play a crucial role in growth, brain development and function and metabolic homeostasis. The sensitivity to TH indices seems to be associated with metabolic syndrome (MS), prediabetes and diabetes in adults. We evaluated the sensitivity to TH indices in a pediatric population with neuromotor disability in relationship with the MS presence, using a multivariate analysis (MVA).Patients and Metho...

hrp0092p1-428 | Thyroid (2) | ESPE2019

Anti-Gastric Parietal Cells Antibodies for Autoimmune Gastritis Screening: A Follow-Up Study in Young Patients with Autoimmune Thyroid Disease.

Calcaterra Valeria , Montalbano Chiara , Vinci Federica , Miceli Emanuela , Regalbuto Corrado , Albertini Riccardo , Larizza Daniela

Introduction: The association between ATD and AIG is very poorly characterized in pediatric age. We review the prevalence of the anti-gastric parietal cells antibodies (APCA) in young patients with ATD and we evaluated the development of AIG during follow-up, in order to define the usefulness of these markers for AIG screening in these patients.Patients and Methods: We evaluated 220 children and adolescents (11.28 ±...

hrp0092p2-64 | Diabetes and Insulin | ESPE2019

Autoimmune Thyroid Diseases in Children and Adolescents with Maturity Onset Diabetes of the Young

Calcaterra Valeria , Regalbuto Corrado , Dobbiani Giulia , Vinci Federica , Montalbano Chiara , Larizza Daniela

Background and Aim: The relationship between T1DM and autoimmune thyreopathies is known and described, but the relationship between thyreopathies and other type of diabetes is not sufficiently clarified in pediatric age. The aim of our study was to assess the prevalence of autoimmune thyroid diseases (ATD) in children and adolescents with maturity onset diabetes of the young (MODY) in comparison with patients with T1DM and control group....

hrp0095p1-596 | Thyroid | ESPE2022

Central and peripheral sensitivity to thyroid hormones and glucose metabolism in childhood obesity.

Corica Domenico , Rosaria Licenziati Maria , Calcaterra Valeria , Currò Monica , Curatola Selenia , Rossi Virginia , Ientile Riccardo , Aversa Tommaso , Wasniewska Malgorzata

Objectives: Increased central and peripheral sensitivity to thyroid hormones seems to be associated with an increased risk of developing prediabetes in adulthood. The objective of this study was to evaluate the relationship between the severity of obesity, the presence of glyco-metabolic alterations, and tissue sensitivity to thyroid hormones in prepubertal euthyroid children with simple obesity.Methods: Eighty prepubert...

hrp0092p1-323 | Diabetes and Insulin (2) | ESPE2019

Diabetes Type 2 in Non-Obese Neurologically Impaired Children and Adolescents: A New Emerging Entity?

Calcaterra Valeria , Regalbuto Corrado , Montalbano Chiara , Vinci Federica , De Silvestri Annalisa , Pelizzo Gloria , Cena Hellas , Larizza Daniela

Background: Insulin resistance (IR) plays a key role in the pathogenesis of type 2 diabetes (T2D). In neurologically impaired (NI) children unfavorable cardio-metabolic risk profile with high prevalence of IR has been reported. We evaluated the prevalence of T2D in NI children and adolescents, in order to define if a dedicated glucose monitoring may be recommended in these subjects.Patients and Methods: We retrospectivel...

hrp0092p3-98 | Fat, Metabolism and Obesity | ESPE2019

High Allostatic Load in Children with Excess of Weight

Calcaterra Valeria , Montalbano Chiara , Vinci Federica , Regalbuto Corrado , Casari Giulia , De Silvestri Annalisa , Cena Hellas , Larizza Daniela

Objective: Allostatic load (AL) refers to the physiological response that occurs in chronic stress burden, Excessive weight gain is an important source of physiological stress promoting chronic low-inflammation state detrimental for health. We estimated AL score among a pediatric population, in order to define a correlation between cumulative biological dysregulation and excess weight.Methods: We enrolled 164 children an...

hrp0092p3-115 | Fat, Metabolism and Obesity | ESPE2019

Gender-Based Differences in the Clustering of Metabolic Syndrome Factors in Children and Adolescents

Calcaterra Valeria , Regalbuto Corrado , Vinci Federica , Montalbano Chiara , Dobbiani Giulia , De Silvestri Annalisa , Cena Hellas , Larizza Daniela

Background: we depicted gender-differences in metabolic syndrome (MS) clustering before and after puberty in pediatrics, to identify early childhood prevention intervention and treatments.Methods: We considered 1079 children and adolescents. According to body mass index (BMI) percentiles the subjects were classified as normal weight BMI<75th, overweight BMI 75-95th and with obesity BMI>95th....

hrp0089p1-p047 | Diabetes &amp; Insulin P1 | ESPE2018

Smoke Exposure and Cardio-metabolic Profile in Youth with Type 1 Diabetes

Calcaterra Valeria , Cena Hellas , Schiamo Luca Maria , Montalbano Chiara , Regalbuto Corrado , De Filippo Maria , Klersy Catherine , Larizza Daniela

Aim: To evaluate the relationship between smoking and metabolic parameters in patients affected by type 1 diabetes (T1D)Patients and methods: We enrolled 104 children and young adults (50 females and 54 males) with T1D (aged 16.4±8.6 years). The subjects were divided into three groups according to their smoking habits: no smoking (NS), passive smoking (PS), active smoking (AS). The physical examination of the participants included nutritional status...

hrp0089p3-p123 | Diabetes &amp; Insulin P3 | ESPE2018

AID-GM System (Advanced Intelligent Distant – Glucose Monitoring) to Monitor Health Status and Metabolic Control of Young People with Type 1 Diabetes

Calcaterra Valeria , Sacchi Lucia , Salvi Elisa , Larizza Daniela , Made Alexandra , Schiano Luca Maria , Montalbano Chiara , Regalbuto Corrado , Bellazzi Riccardo , Larizza Cristiana

Aim of the study: In type 1 diabetes, it is well recognized that collecting additional information about diet, physical activity, health status, stress and any patients’ everyday behavior, is crucial to evaluate accurately metabolic control and therapeutic prescription adherence. The aim of this study is to test AID-GM (Advanced Intelligent Distant – Glucose Monitoring) a web-based platform, able of collecting automatically patient generated health data (PHGD) coming...

hrp0089p2-p126 | Fat, Metabolism and Obesity P2 | ESPE2018

Serum Calprotectin Level in Children: Marker of Obesity and Its Metabolic Complications

Calcaterra Valeria , Amici Mara De , Silvestri Annalisa De , Michev Alexandre , Montalbano Chiara , Regalbuto Corrado , Schiano Luca Maria , Cena Hellas , Larizza Daniela

Aim: Circulating levels of calprotectin have been reported in obesity-related chronic low-grade inflammation in adults, but has not been evaluated in pediatric population. We investigated serum calprotectin in overweight and obese children and its association with metabolic comorbidities.Methods: We enrolled 131 children (11.7±4.1 years). According to BMI, the subjects were divided into three groups: obese >95th percentile; overweight BMI 75th&#...