ESPE Abstracts

Methods: We performed retrospective study using database of the patients with congenital hypothyroidism treated with or without Levo-Thyroxine at Bundang Jesaeng General Hospital, from January 1998 to February 2016. Their ages, birth weights, gestational ages, symptoms, ages at diagnosis and treatment were recorded. We measured TSH, free thyroxine (FT4), triiodothyronine (TT3) levels at diagnosis and treatment, and those levels at one, two and three months after treatment. Thy...

Purpose: The goal of treatment for true precocious puberty (TPP) and early puberty with GnRH agonist (GnRHa) is to prevent loss of genetic potential of target height (TH). And to regress secondary sex characteristics appropriate for patient’s age. But some patient’s growth velocity (GV) after treatment would decline and suggest that final height (FH) was not improved. So, we investigated the effect of combined GH and GnRHa treatment for near-FH (NFH) improvement....

Background: The recent articles showed a kind of associations of the serum vitamin D levels and chronic diseases, for example, autoimmune diseases, vascular disorders, as well as malignancies. Also vitamin D deficiency impacts normal growth and maximal bone mineral accretion in puberty. Of pediatric population in Korea, the prevalence of cases of vitamin D deficiency and precocious puberty were continuously increasing nowadays.Objective and hypotheses: W...

Background: It is well known that obesity, diabetes or chronic disease are related with nutrition. However it has not been known whether health providers have concepts or competence about counseling of nutritional support in clinical practice basis. There is rare of information about differences among types of profession jobs.Objective and hypotheses: We investigated a survey with standardized questionnaire tool among different types of profession jobs d...

Background: Early age at menarche was associated with obesity, insulin resistance, metabolic syndrome, cardiovascular disease (CVD), and mortality in adulthood. Besides, a mother's age at menarche has been suggested to be a likely contributor to a daughter's early menarche. Therefore, this study aimed to determine whether a mother's earlier age at menarche is a risk factor for a daughter's early menarche, obesity, and short stature in young...

Background: Obesity is a well-recognized complication of craniopharyngioma. Increased hypothalamic involvement (HI) by the tumour and accordant treatment has been associated with greater obesity. Changes in hypothalamic control of the autonomic nervous system (ANS) have been implicated in the development of hypothalamic obesity however, long term changes in the ANS have not been assessed.Objective and hypotheses: We aimed to evaluate ANS activity using h...

Introduction: Deficient anterior pituitary with variable immune deficiency (DAVID) syndrome is a rare condition characterized by symptomatic ACTH deficiency and primary hypogammaglobulinemia, caused by a heterozygous mutation in the NFKB2 gene (MIM#164012) on chromosome 10q24. We report the novel mutation of the NFKB2 gene in a Korean boy presenting with gait disturbance, calf pain, and abnormal thyroid function test.<s...

Objective: The present study aimed to evaluate the association of free thyroxine (FT4) and TSH with insulin resistance indices in euthyroid Korean children and adolescents using nationally representative data.Methods: A total of 259 children and adolescents were included in data from The Korean National Health and Nutrition Examination Survey 2015.Results: TSH levels were significantly positively associated with HOMA-IR (β...

Introduction: Treatment with recombinant human growth hormone (rhGH) is useful for growth failure in short stature children. But there are some reports of renal disease or complication occurring during rhGH treatment. GH and insulin-like growth factor-1 (IGF-1), together with other growth factors and cytokines, have important roles in adaptive morphological and functional changes in the kidney. This study was aimed to reveal the renal complication of hematuria...

Background: Phthalates are synthetic chemicals produced in extremely large volumes for a wide variety of uses in personal care and consumer products, including building materials, food packaging, medical devices, toys and cosmetics. Though a few studies have shown that concentrations of phthalate metabolites are associated with obesity and insulin resistance in adults, studies in children are limited.Objectives: We studied to examine the associations of ...